Despite being settled as far back as 1719 and even being the capital of Louisiana from 1720 to 1723, Biloxi was not of much interest to the kindred of the New World until after its incorporation into a township in 1838, when it was transforming into a summer resort for rich Southerners. Citizens of New Orleans would flee here during the regular yellow fever epidemics and the wealthier bought large homes on the waterfront. During this period, the influence of Lafitte and the Acadian Sabbat in Houma kept the Camarilla from making any headway into the city, but no effort was made by the Sabbat to permanently claim it.
This state of affairs changed after the Civil War, when the Sabbat began to regret that they hadn't put a pawn of some sort in the city. With Lafitte's support, the Camarilla were able to place a Prince here. The turmoil caused by the city's occupation allowed him to purge it of Sabbat influence and establish his own pawns. Canning became the primary industry and Landau was in on the ground floor.
The problems created by economic fluctuations and the tempestuous gulf weather have made it a difficult city to rule, and this hasn't been made easier by the arrival of the Giovanni in the 1950s. For the latter half of the century, through Hurricane Camille and the collapse of the oil industry in the 1980s, the two kindred have warred over control of the city while trying to keep the Sabbat from ousting them both. Things have only become more heated in the 1990s, with the legalization of dockside gambling. Already something of a resort town, this influx of money and tourists has only sweetened the pot.